Microtubule interaction of LICC1, a maize homologue of a component of the human muskelin/RanBPM/CTLH protein complex

MRCTLH (muskelin/RanBPM/CTLH) is a protein complex found in humans (MRCTLH) that involved the regulation of numerous cellular processes, such as gluconeogenesis, cell signaling, development, nuclear extrusion, morphology, or stability different proteins. According to genomic data, all eukaryotes have similar complexes. In yeast, named GID was be gluconeogenesis. LICC1 maize whose sequence resembles TWA1 and GID8 which are central components contains three highly conserved domains, LisH, CTLH, CRA, typical this family. Twa1 gid8 unique genes human yeast genomes. However, copies licc1 present genome multiple other plant This result suggests presence variants MRCTLH/GID plants, could increase its regulatory capacity. We also demonstrate here has ability interact with microtubules, similarly TWA1. interaction reinforces idea from maize, homologues plants and, general, GID/MRCTLH can perform biological functions those yeast.